Biomimetic modification of silicone tubes using sodium nitrite-collagen immobilization accelerates endothelialization.

Sustained release of growth hormone and sodium nitrite from biomimetic collagen coating immobilized on silicone tubes improves endothelialization.

Biocompatibility of biomedical devices can be improved by endothelialization of blood-contacting parts mimicking the vascular endothelium's function. Improved endothelialization might be obtained by using biomimetic coatings that allow local sustained release of biologically active molecules, e.g. anti-thrombotic and growth-inducing agents, from nanoliposomes. We aimed to test whether incorpora...

Surface modification of silicone tubes by functional carboxyl and amine, but not peroxide groups followed by collagen immobilization improves endothelial cell stability and functionality.

Surface modification by functional groups promotes endothelialization in biohybrid artificial lungs, but whether it affects endothelial cell stability under fluid shear stress, and the release of anti-thrombotic factors, e.g. nitric oxide (NO), is unknown. We aimed to test whether surface-modified silicone tubes containing different functional groups, but similar wettability, improve collagen i...

The Study of Collagen Immobilization on a Novel Nanocomposite to Enhance Cell Adhesion and Growth

Background: Surface properties of a biomaterial could be critical in determining biomaterial’s biocompatibility due to the fact that the first interactions between the biological environment and artificial materials are most likely occurred at material’s surface. In this study, the surface properties of a new nanocomposite (NC) polymeric material were modified by combining plasma treatment and...

Collagen Immobilization onto Acrylic Acid Laser-grafted Silicone for Using as Artificial Skin: In Vitro

A biomimetic peptide fluorosurfactant polymer for endothelialization of ePTFE with limited platelet adhesion.

Endothelialization of expanded polytetrafluoroethylene (ePTFE) has the potential to improve long-term patency for small-diameter vascular grafts. Successful endothelialization requires ePTFE surface modification to permit cell attachment to this otherwise non-adhesive substrate. We report here on a peptide fluorosurfactant polymer (FSP) biomimetic construct that promotes endothelial cell (EC)-s...